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Updated: Jul 19, 2025

Single-Molecule Imaging of Nuclear Transport
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用量子传感器进行单细胞核磁共振光谱学的前景

Nick R Neuling1, Robin D Allert1, Dominik B Bucher1

  • 1Technical University of Munich, TUM School of Natural Sciences, Department of Chemistry, Lichtenbergstr. 4, 85748 Garching b. München, Germany; Munich Center of Quantum Science and Technology (MCQST), Schellingstr. 4, 80779 München, Germany.

Current opinion in biotechnology
|August 13, 2023
PubMed
概括

新型钻石空位 (NV) 传感器通过启用核磁共振 (NMR) 光谱来提供非侵入性单细胞分析. 这种量子传感方法有望揭示以前由批量测量隐藏的细胞化学细节.

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Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
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When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
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