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过度的头发皮质醇度作为儿童心理障碍的指标
Astrid Brænden1, Andrea Lebena2, Åshild Faresjö2
1Oslo University Hospital, Division of Mental Health and Addiction, Oslo, Norway.
Psychoneuroendocrinology
|August 13, 2023
概括
患有心理障碍的儿童,包括扰乱性情绪失调障碍 (DMDD),表现出头发皮质醇度升高 (HCC),表明长期的下丘脑-垂体-上腺 (HPA) 轴活动. 这表明HCC可能作为儿童心理状况的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 儿童心理学 儿童心理学
背景情况:
- 头发皮质醇度 (HCC) 是一种用于评估长期下丘脑-垂体-上腺 (HPA) 轴活动的新生物标志物.
- HPA轴活动与情绪调节密切相关.
- 了解心理障碍儿童的HPA轴功能对于诊断和治疗至关重要.
研究的目的:
- 为了比较患有扰乱性情绪失调障碍 (DMDD),其他心理障碍和健康对照儿童的头发皮质醇度 (HCC).
- 研究这些群体中HCC,易怒,年龄和性别之间的关系.
- 确定HCC是否可以作为儿童心理障碍的指标.
主要方法:
- 收集了头发样本来测量皮质醇度.
- 参与者包括患有DMDD的临床转诊儿童 (n=19),其他心理障碍 (n=48) 和健康受试者 (n=36).
- 进行了统计分析,以比较不同组的HCC,并检查与临床变量的相关性.
主要成果:
- 与健康儿童相比,患有DMDD和其他心理障碍的儿童表现出明显更高的HCC (p < .001).
- 在患有DMDD的儿童和患有其他心理障碍的儿童之间,没有发现HCC的显著差异 (p = .91).
- 在DMDD组中观察到HCC和年龄之间的负相关性 (r = -0.54,p < .05),但在健康组中没有.
结论:
- 需要心理治疗的儿童,包括患有DMDD的儿童,似乎对HPA轴的长期失调.
- 头发皮质醇度升高可能表明儿童有潜在的心理障碍.
- 在儿童群体中,HCC提供了一种有价值的非侵入性方法来评估慢性压力和HPA轴功能.
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