关于T细胞免疫力以及孕前的病因和发病原因
Shigeru Saito1, Sayaka Tsuda1, Akitoshi Nakashima1
1Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama, Japan.
Journal of reproductive immunology
|August 13, 2023
概括
孕前症可能源于母亲对胎儿免疫耐受性减弱. 关键的免疫细胞,调节性T细胞和CD8+效应记忆T细胞,显示功能减弱,可能导致胎儿排斥.
科学领域:
- 免疫学 免疫学 免疫学
- 生殖免疫学 生殖免疫学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 孕前的发生率在与新伴侣的第一次怀孕,捐赠卵子怀孕和短暂的共同生活中更高.
- 流行病学数据表明,对父/胎儿抗原的耐受性受损有助于孕前的发病.
- 免疫调节失调与妊娠并发症有关,如先兆子和复发性怀孕丧失 (RPL).
研究的目的:
- 探索孕前的基础免疫机制,重点关注孕产妇对胎儿的耐受性.
- 为了区分妊娠前的免疫环境与重复性妊娠损失的免疫环境.
- 研究调控T细胞 (Treg),CD8+效应体记忆T细胞 (TEM) 和Th17细胞在孕前中的作用.
主要方法:
- 综述流行病学发现和免疫学研究对孕前和RPL.
- 对调节性T (Treg) 细胞的变化和CD8+效应体内存T (TEM) 细胞上的PD-1表达的分析.
- 研究Th17细胞分化和可溶性内素和TGFβ的作用.
主要成果:
- 孕前与父/胎儿抗原特异性Treg细胞减少和CD8+TEM细胞PD-1表达减少有关,这表明耐受性下降.
- 相比之下,RPL显示总Treg细胞减少和克隆扩展的CD8+TEM细胞增加.
- 孕前炎症表现出增加的Th17细胞分化,与高水平的可溶性内分泌素中和TGFβ有关.
结论:
- 孕前的发病可能涉及特定调节性T细胞的减少和PD-1表达的受损,从而损害了母胎的耐受性.
- 在孕前和RPL中,不同的免疫特征突出显示出妊娠失败的不同机制.
- 孕前的免疫变化增加了胎儿对母亲免疫攻击的敏感性.
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