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强迫症障碍中区域自发大脑活动的变化:元分析
Huayun Li1, Yihe Wang1, Hongyu Xi2
1School of Psychology, Zhejiang Normal University, Jinhua, China; Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province, Zhejiang Normal University, Jinhua, China; Intelligent Laboratory of Zhejiang Province in Mental Health and Crisis Intervention for Children and Adolescents, Jinhua, China.
Journal of psychiatric research
|August 13, 2023
概括
这一元分析揭示了强迫症 (OCD) 患者的大脑活动的改变. 额叶,感觉运动皮质,小脑和胰岛的关键大脑区域都与强迫症的病理生理学有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 强迫症 (OCD) 与异常的区域性自发大脑活动有关.
- 之前的休息状态功能磁共振成像 (rs-fMRI) 研究显示了关于强迫症受影响的大脑区域和活动方向的矛盾发现.
- 进行元分析对于确定强迫症患者大脑活动变化的一致模式至关重要.
研究的目的:
- 在强迫症患者中对自发大脑活动进行系统的元分析.
- 用定量审查来确定区域大脑活动中一致的异常.
- 为了阐明强迫症的神经生物学基础.
主要方法:
- 在PubMed,Web of Science和Embase的系统文献搜索到2023年5月.
- 包括测量区域同质性 (ReHo),低频波动幅度 (ALFF) 和低频波动分数幅度 (fALFF) 的研究.
- 基于种子的d绘图 (AES-SDM) 的无otropic效果大小版本的应用,用于元分析.
主要成果:
- 对27项涉及1256名强迫症患者和1176名健康对照者的研究进行了分析.
- 在强迫症患者中观察到右下垂体环,左中环环环环环环环环环环环环环环,双边下小脑,右中前环环环环,左下前环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环环
- 在右前中心环,右内环,左后中心环,双边上大脑和左尾状环中发现的自发性大脑活动减少.
结论:
- 这一元分析提供了对强迫症中自发大脑活动变化的定量概述.
- 额叶,感觉运动皮质,小脑,尾状细胞和岛状细胞是参与强迫症病理生理学的关键大脑区域.
- 研究结果提供了关于强迫症病理生理机制的见解,以及未来诊断和治疗的潜在途径.
