马卢斯巴卡塔 (Linn.) 的意思 装载着Borkh多的纳米颗粒通过调节肠道功能和肠道微生物群来改善肠道健康
Lu Wang1, Zhen Li1, Siying An1
1Skate Key Laboratory of Metastable Materials Science and Technology, Nano-biotechnology Key Lab of Hebei Province, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, China.
International journal of biological macromolecules
|August 13, 2023
概括
来自果多和菌多糖的新纳米颗粒在小鼠中没有毒性. 这些新型纳米颗粒通过增强有益细菌和减少有害细菌来改善肠道健康,这表明益生菌的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 来自Malus baccata (MBP) 的多具有健康益处,但需要有效的输送系统.
- 霍恩布埃赫利亚 (Hohenbuehelia) 血清素多糖 (HSP) 和粘素为纳米粒子配方提供了潜力.
- 开发安全有效的输送系统对于提高多生物可用性和功能至关重要.
研究的目的:
- 使用Hohenbuehelia serotina多糖和粘素 (MBP-MC-HSP NP) 构建封装Malus baccata多的纳米颗粒.
- 在小鼠模型中评估MBP-MC-HSPNP对肠道功能和肠道微生物群的安全性和有效性.
- 探索MBP-MC-HSPNP作为营养食品部门功能益生菌的潜力.
主要方法:
- 纳米粒子合成使用Hohenbuehelia 血清素多糖和素用于Malus baccata聚烯封装.
- 通过小鼠的器官指数和血液学参数分析进行体内安全性评估.
- 通过结肠指数,长度,组织学,便水分,周静止和排便时间来评估肠功能.
- 使用16S rRNA测序和代谢概况 (KEGG,COG数据库) 的肠道微生物群分析.
主要成果:
- MBP-MC-HSP NPs没有显示出毒性或不良影响.
- 在结肠指数,长度和组织学方面观察到显著的改善.
- 便水分增加,肠周平静加速,排便时间缩短.
- MBP-MC-HSP NPs调节了肠道微生物群的组成,增加了有益的细菌 (乳杆菌,白菌,鲁米诺菌),减少了有害的细菌 (Prevotella,Bifidobacterium,Desulfovibrio). 通过调节肠道微生物群的组成,增加了有益的细菌 (乳杆菌,白菌,鲁米诺菌),减少了有害的细菌 (Prevotella,Bifidobacterium,Desulfovibrio).
- 增强了短链脂肪酸 (酸,酸,n-黄油酸) 的产生,降低了结肠的pH值.
- 肠道微生物群的代谢概况受到积极影响.
结论:
- MBP-MC-HSP NP在改善小鼠肠道功能和调节肠道微生物群方面是安全有效的.
- 这些纳米颗粒增强有益的肠道细菌和短链脂肪酸的产生,有助于肠道健康.
- 在营养食品行业中,MBP-MC-HSP NP显示出开发和应用作为益生菌的显著前景.
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