呈现时的种族和性别相关差异在角缩性心肌病:一个观察性横截面研究
Shafik Khoury1, Raghav T Bhatia1, Sarandeep Marwaha1
1Cardiovascular Clinical Academic Group, St. George's, University of London, St. George's University Hospitals NHS Foundation Trust, United Kingdom.
International journal of cardiology
|August 13, 2023
概括
种族和性别会影响心肌缩性心肌病 (ApHCM) 的表现. 黑人患者和高血压男性表现出混合型高,而女性在晚些时候表现出较少的心电图变化.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 医疗成像医学成像
背景情况:
- 亚皮性多变性心肌病 (Apical hypertrophic cardiomyopathy,ApHCM) 是一种多变性心肌病的独特形式.
- 了解临床表现和心血管磁共振 (CMR) 发现的变异对于患者管理至关重要.
- 调查种族和性别的影响可以揭示ApHCM中重要的人口差异.
研究的目的:
- 确定种族和性别是否与不同临床表现的ApHCM有关.
- 为了确定心血管磁共振 (CMR) 结果的变化,基于apHCM患者的种族和性别.
- 探索ApHCM患者的人口和临床差异.
主要方法:
- 来自英国第三级推中心的150名连续ApHCM患者的回顾性观察队列研究 (2010-2020).
- 收集的数据包括人口统计,临床信息,12导电心电图 (ECG) 和CMR发现.
- ApHCM表型被归类为"纯" (孤立的顶顶缩) 或"混合" (顶顶缩和隔膜缩具有更大的顶顶壁厚度).
主要成果:
- 女性比男性晚诊断,表现出较少突出的心电图变化,较高的左心房区域指数和高血压的增加.
- 黑人患者的左心室质量指数更高,高血压更高,以及"混合"ApHCM类型的患病率更高.
- 高血压男性主要呈现"混合"表型.
结论:
- 患有高血压的黑人种族和男性性别与混合的顶峰和基底缩有关.
- 白人,亚洲人和没有高血压的男性往往只限于顶部的高血压.
- 雌性在年龄较大时出现,并且在心电图上不太可能表现出深度T波逆转.
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