病毒感染和慢性鼻炎
Sophia Volpe1, Joseph Irish1, Sunny Palumbo1
1Department of Otolaryngology-Head and Neck Surgery, College of Medicine, University of Arizona, Tucson, Ariz.
The Journal of allergy and clinical immunology
|August 13, 2023
概括
病毒感染可以通过破坏鼻腔内膜和改变免疫反应来引发慢性鼻炎 (CRS). 了解这些病毒触发器是开发CRS新疗法的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 病毒感染是上呼吸道感染的常见原因,通常是自我限制的.
- 然而,一些病毒感染可能会引发慢性鼻炎 (CRS),并导致长期和严重的症状.
- 病毒感染鼻上皮质,引发先天性和潜在的2型免疫反应.
研究的目的:
- 审查涉及CRS病原体的常见病毒.
- 在鼻腔表皮上识别病毒结合受体.
- 阐明病理生理机制,将病毒感染与CRS联系起来.
主要方法:
- 关于病毒感染和CRS的文献综述.
- 对病毒结合受体和鼻上皮层相互作用的分析.
- 检查免疫反应,包括细胞因子的产生和屏障功能的改变.
主要成果:
- 病毒利用特定的受体进入鼻上皮细胞.
- 病毒感染可能会破坏粘膜清除和上皮屏障完整性.
- 异常免疫反应,包括2型炎症,都与CRS发展有关.
结论:
- 病毒感染在慢性鼻炎的发病过程中起着重要作用.
- 了解病毒机制为CRS发展和潜在的治疗点提供了洞察力.
- 对病毒-上皮相互作用和免疫失调的进一步研究对于CRS管理是有必要的.
相关概念视频
Chronic Pharyngitis
2.8K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
2.8K
Drugs Used in Upper Respiratory Disorders: Overview
290
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
290
Common Respiratory Disorders
676
Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
676
Tonsillitis I: Introduction
318
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
318
Acute Pharyngitis
845
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
845
Anatomy of Respiratory System I: Upper Respiratory Tract
1.8K
The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
1.8K


