中枢神经系统的淋巴增殖障碍二次的甲托雷克萨特:一个系统的文献综述和案例说明
Alexander In1, Brittany M Stopa1, Joshua A Cuoco2
1Department of Neuroscience, Fralin Biomedical Research Institute, Roanoke, Virginia, USA; Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA.
甲基相关的淋巴增殖障碍 (MTX-LPD) 是一种罕见的中枢神经系统并发症. 迅速停止MTX为MTX-LPD患者提供了良好的预后.
科学领域:
- 神经免疫学 神经免疫学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲基 (MTX) 是一种免疫抑制剂,用于治疗类风湿性关节炎等炎症性疾病.
- 中枢神经系统 (CNS) 的不良影响,包括MTX相关的淋巴增殖障碍 (MTX-LPD),是罕见但严重的并发症.
- 关于中枢神经系统MTX-LPD的自然史,治疗和结果的文献有限.
结论:
- 在有神经症状的MTX用户中,必须考虑CNS MTX-LPD.
- 立即停止使用MTX与良好的预后有关.
- 在30.8%的病例中,死亡发生在发病后平均11个月内.
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