在中年和老年非糖尿病人群中,甘油三指数与中风之间的关联:前性队列研究
Yanbo Yu1, Ying Meng1, Jing Liu1
1Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
通过甘油三糖-葡萄糖 (TyG) 指数测量胰岛素耐药性,显著增加非糖尿病老年人中风风险. TyG指数可以帮助预测公共卫生倡议中风风险.
科学领域:
- 心血管疾病流行病学
- 代谢综合征研究 代谢综合征研究
背景情况:
- 关于非糖尿病人的胰岛素抵抗 (IR) 和中风风险的数据有限.
- 甘油三糖 (TyG) 指数是IR的标志物.
研究的目的:
- 调查TyG指数与中风风险之间的关联.
- 专注于没有糖尿病的中年和老年中国人.
主要方法:
- 17,708名非糖尿病参与者 (≥45岁) 来自中国健康与退休长度研究.
- 根据TyG指数四分之一分类参与者.
- 随访时间中位数为7年,监测中风事件.
主要成果:
- 增加的TyG指数四分位数与明显更高的中风发病率相关.
- 在Q2,Q3,Q4和Q1的危险比率分别为1.64,1.65和1.76.
- 泰格指数改善了中风预测模型 (IDI 0.17%,NC 17.91%).
结论:
- 泰格指数与非糖尿病老年人中风风险增加有显著关联.
- 泰格指数显示出作为预测中风风险的临床和公共卫生工具的潜力.
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