在COVID-19之后的变种特定症状:在广岛的一项基于医院的研究
Kanon Abe1, Aya Sugiyama1, Noriaki Ito2
1Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University.
Journal of epidemiology
|August 13, 2023
概括
新型冠状病毒疾病 (COVID-19) 恢复后的持续症状因严重急性呼吸系统综合征冠状病毒2菌株而异. 与野生型相比,Omicron感染与更多的呼吸道症状有关,但味觉/嗅觉障碍较少.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 后COVID-19恢复症状,或长期COVID,仍然不完全理解.
- 不同严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 菌株对长期COVID症状学的影响在很大程度上未确定.
- 了解特定菌株的COVID-19后症状对于有效的患者管理和公共卫生策略至关重要.
研究的目的:
- 调查和描述COVID-19患者康复后患者经历的症状.
- 为了确定症状概况是否根据感染期间流行的SARS-CoV-2菌株 (野生型,阿尔法,三角形,欧米克朗) 不同.
- 为了确定与特定症状集群相关的风险因素,COVID-19后恢复.
主要方法:
- 一项基于问卷的研究,涉及385名患者,他们在COVID-19后参加了后续咨询.
- 根据COVID-19发病期,患者被分为四组:野生型,阿尔法,三角型和Omicron.
- 使用分层集群分析和多变量分析来识别症状集群和相关的风险因素.
主要成果:
- 在385名患者中,有249名患者 (64.7%) 报告在发病后平均23.5天内持续出现症状.
- 确定的症状集群包括嗅觉/味觉障碍,呼吸道和心脏症状.
- 与野生型相比,Omicron感染与增加的呼吸道症状 (AOR 3.13) 和减少的嗅觉/味觉障碍 (AOR 0.14) 相关联.
- 需要氧气/通风支持的患者在康复后出现的呼吸症状较少 (AOR 0.46),但心脏症状较多 (AOR 2.67).
结论:
- COVID-19 恢复症状依赖于菌株,突出显示了长期COVID的不断变化的性质.
- 与早期菌株相比,Omicron变异与一个独特的症状概况有关.
- 急性疾病的严重程度会影响COVID-19后症状的类型和频率,这对有针对性的后续护理有影响.
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