乳腺癌患者的心血管疾病在现代时代得到治疗

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Alexandra C Murphy¹, Anoop N Koshy², Omar Farouque²

¹Department of Cardiology, Austin Health, Melbourne, Vic, Australia; Department of Medicine, The University of Melbourne, Vic, Australia; Department of Oncology, The Olivia Newton John Cancer and Wellness Centre, Melbourne, Vic, Australia.

Heart, lung & circulation

|August 13, 2023

概括

一个新的乳腺癌心血管风险指数 (CRIB) 工具有助于识别患有重大心血管不良事件 (MACE) 高风险的乳腺癌幸存者. 这种工具有助于指导心脏监测和这些患者的保护疗法.

科学领域:

在瘤学瘤学.
心脏病学心脏病学
流行病学流行病学

背景情况:

心血管疾病 (CVD) 是乳腺癌 (BC) 幸存者死亡的主要原因.
现有的风险评估工具并不专门针对这种不断增长的患者群体.
需要一个经过验证的工具来预测BC幸存者的长期心血管结果.

研究的目的:

为了研究早期BC患者的长期心血管结果.
推导和验证一种新的风险评估工具,即乳腺癌心血管风险指数 (CRIB),用于预测主要心血管不良事件 (MACE).

主要方法:

在2009-2019年期间接受治疗的1173名早期BC患者的回顾性队列研究.
评估MACE和预测因素,包括年龄,心血管风险因素和冠状动脉疾病史.
开发和验证CRIB得分 (功能障碍,年龄≥65,BMI>27,糖尿病,高血压,吸烟史).

主要成果:

80名 (6.8%) 患者在4.4年的中位随访期间经历了MACE.
较高的MACE风险与年龄较大,心血管风险因素和先前冠状动脉疾病有关.
一个CRIB得分≥3 (代表队列的23.9%) 显示了中度的歧视 (c-统计值0.75) 并与明显增加的MACE风险 (OR17.85,p<0.001) 相关.
在经历MACE的患者中,死亡率更高 (HR2.72,p<0.001).

结论:

新的CRIB得分可以有效地分层心血管风险在早期的BC患者在诊断时.
CRIB可以指导监测策略和心脏保护疗法的实施.
这个工具可以帮助识别需要长期心脏随访的BC幸存者.

关键词:

乳腺癌是什么? 乳腺癌是什么?心脏瘤学 - 心脏瘤学心血管疾病的危险因素风险估计风险估计

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