慢性肺病和心血管疾病的相互关系基于两个国家前性队列研究
Xueling Ren1, Shengshu Wang2, Junsong Lian3
1Department of Respiratory, National Clinical Research Center for Geriatrics Diseases, The Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Heart, lung & circulation
|August 13, 2023
概括
慢性肺病 (CLDs) 会增加老年人心血管疾病 (CVD) 的风险,反之亦然. 体重指数和抑郁症可能是这种联系的媒介.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 老年学是一门学科.
背景情况:
- 慢性肺部疾病 (CLDs) 和心血管疾病 (CVDs) 构成了全球重大健康负担.
- 了解CLD和CVD之间的相互关系对于公共卫生战略至关重要.
研究的目的:
- 估计慢性肺部疾病和心血管疾病之间的相互关系.
- 在中国成年人中调查CLD和CVD之间的潜在调解途径.
主要方法:
- 利用了两个大型的中国国家纵向队列研究:CHARLS (n=15,052) 和CLHLS (n=9,765).
- 采用Cox的比例风险模型来评估CLD和CVD之间的关联.
- 分析了BMI和抑郁症状 (CES-D-10) 对CLD-CVD关系的调解效应.
主要成果:
- 慢性心血管疾病是发生性心血管疾病 (HR 1.49) 和不包括中风的心血管疾病 (HR 1.76) 的重要预测因素.
- 在查尔斯队列中,心血管疾病也是CLD (HR 1.40) 的重要预测因素.
- 关联是由身体质量指数 (BMI) 和抑郁症状 (CES-D-10分数) 调解的.
结论:
- 慢性肺病与中年和老年社区人口中心血管疾病发病率增加有关,反之亦然.
- 体重指数和抑郁症状可能在CLD对心血管疾病的影响中起着调解作用.
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