大脑结构和认知的年龄,性别和病理相关的变化
Dario Bachmann1,2, Andreas Buchmann3, Sandro Studer3
1Institute for Regenerative Medicine, University of Zurich, Schlieren, Switzerland. dario.bachmann@irem.uzh.ch.
Translational psychiatry
|August 13, 2023
概括
年龄和大脑成像标志物,如粉样蛋白和蛋白PET扫描显示早期的认知变化. 这些发现突出了老化和认知障碍中不同的病理途径和性别特异性的脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 认知科学 认知科学
背景情况:
- 衰老与认知能力下降和神经病理学有关.
- 早期检测认知变化和潜在病理非常重要.
研究的目的:
- 为了研究将年龄,神经成像标记 (粉样和质PET,MRI) 和认知功能联系在一起的途径.
- 探索这些关联中的性别差异.
主要方法:
- 结构方程建模用于分析232名老年人 (50-89岁) 的数据.
- 测量包括粉样PET,型PET (亚样本),MRI和神经心理测试.
- 分析检查了年龄,生物标志物负担,大脑结构和认知表现之间的关系.
主要成果:
- 年龄对大多数认知和成像指标产生了负面影响.
- 侧腔室体积增加与执行功能障碍相关.
- 脑内皮层中陶负担与粉样蛋白阳性个体中较差的情节性记忆有关.
- 粉样蛋白负担与女性缩的关联较强,可能由介导.
结论:
- 影响认知和性别特异性脆弱性的病理途径即使在早期神经病理学中也是可分离的.
- 研究结果表明,有不同的机制导致认知衰老和衰弱.
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