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关怀RET改变的甲状腺癌患者的挑战:一个多国混合方法研究

Suzanne Murray¹, Vivek Subbiah², Steven I Sherman²

¹AXDEV Group Inc, 210-8, Place du Commerce, Brossard, Québec, J4W 3H2, Canada. murrays@axdevgroup.com.

Thyroid research

|August 13, 2023

概括

医疗保健提供者需要更多的教育来评估遗传风险,选择生物标志物,并管理RET改变的甲状腺癌患者的副作用. 这对于将新的向疗法纳入临床实践至关重要.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
药理学药理学是指药理学的学科.

背景情况:

甲状腺癌 (TC) 向治疗的进步需要对RET突变进行生殖线检测.
选择性RET抑制剂越来越多地得到批准,改变了TC治疗范式.
在为RET改变的TC患者提供最佳护理方面存在挑战.

研究的目的:

确定医疗保健提供者在管理RET改变TC的患者时所面临的挑战和障碍.
评估提供者关于RET向治疗的教育和行为需求.

主要方法:

在德国,日本,英国和美国进行了混合方法需求评估.
参与者包括医学瘤学家,内分泌学家和临床病理学家.
通过44次采访和378次调查收集数据,并进行了定性和定量分析.

主要成果:

提供者自认为在遗传风险评估 (56%),生物标志物选择 (59%),治疗启动 (65%),副作用管理 (78%) 和息护理转移 (58%) 中的知识不足.
系统性障碍阻碍了RET分子测试和选择性抑制剂的使用.
提供者需要提高技能来管理向治疗的安全性和有效性.

结论:

这项研究突出了为照顾RET改变的甲状腺癌患者的提供者特别的教育需求.
调查结果可以指导开发基于证据的教育干预措施.
需要进行干预,以支持新批准的RET选择性抑制剂在临床实践中的整合.

关键词:

提供医疗保健服务.内分泌学在内分泌学.医学瘤学医学瘤学病理学病理学病理学在RET基因突变中发生突变.甲状腺癌甲状腺癌是什么?

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