泰莫西林在门诊亲肠道抗菌药物治疗中的稳定性:这是一个真正的选择吗?
Beatriz Fernández-Rubio1, Laura Herrera-Hidalgo1,2, Luis E López-Cortés3,4,5
1Unidad de Gestión Clínica de Farmacia, Hospital Universitario Virgen del Rocío/Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain.
The Journal of antimicrobial chemotherapy
|August 14, 2023
概括
泰莫西林在输液袋和弹性体器件中的门诊亲肠道抗菌疗法 (OPAT) 中在高达32°C的温度下稳定. 这种稳定性支持其在OPAT计划中用于易受肠杆菌菌类感染的OPAT程序.
科学领域:
- 药物稳定性 药物稳定性
- 抗菌疗法是一种抗菌疗法.
- 分析化学 分析化学
背景情况:
- 泰莫西林是一种可行的替代品,用于治疗Enterobacteriaceae感染.
- 它在门诊亲肠道抗微生物治疗 (OPAT) 中的应用是有希望的,但由于缺乏稳定性数据而受到限制.
研究的目的:
- 在与OPAT相关的条件下评估泰莫西林的物理和化学稳定性.
- 在不同温度下评估聚烯输液袋和聚烯弹性体器件中的泰莫西林稳定性.
- 开发和描述一种新的LC-MS/MS方法来定量泰莫西林.
主要方法:
- 泰莫西林 (6g在500mL0.9%NaCl中) 在4°C,25°C,32°C和37°C的输液袋和弹性中存储72小时.
- 通过监测颜色,清晰度,pH值和药物度 (≥90%的完整药物) 来评估稳定性.
- 采用一种新的液体染色学-双重质谱法 (LC-MS/MS) 方法进行量化.
主要成果:
- 在整个72小时的研究期间,在4°C,25°C和32°C的温度下,Temocillin在两种设备中都保持了≥90%的度.
- 在37°C时,泰莫西林在24小时内保持稳定,之后其度下降到90%的值以下.
- 没有观察到降水,只注意到轻微的颜色变化.
结论:
- 泰莫西林表现出足够的稳定性,可在高达32°C的温度下在OPAT环境中使用.
- 该药物是OPAT计划的合适候选者,允许患者在家完成治疗.
- 一种经过验证的LC-MS/MS方法已成功开发用于泰莫西林分析.
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