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用于预防亚托皮性湿疹的软化剂:BEEP试验的成本效益分析

Tracey H Sach¹, Stella T Lartey¹, Charlotte Davies²

¹Health Economics Group, Norwich Medical School, University of East Anglia, Norwich, UK.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

|August 14, 2023

概括

在婴儿期每天使用软化剂预防高风险婴儿的湿疹是不具有成本效益的. 在BEEP试验中,没有发现湿疹发病率的显著降低或质量调整寿命年 (QALYs) 的改善,以证明成本是合理的.

科学领域:

皮肤病学皮肤病学
儿科儿科儿科
卫生经济学卫生经济学

背景情况:

新出现的证据表明,从出生开始加强皮肤屏障可以预防湿疹和食物过敏.
主动增强皮肤屏障是预防早年亚托皮性疾病的潜在策略.

研究的目的:

评估日常全身软化剂在生命的第一年应用的成本效益,以预防高风险儿童的亚托皮性湿疹.
分析2年和5年期间的医疗服务成本和质量调整寿命年 (QALYs).

主要方法:

在试验中使用BEEP试验数据进行了试验内经济评估.
1394名高风险婴儿被随机分配到每天接受软化剂应用或常规护理.
成本效益是通过增量成本效益比率 (ICER) 来衡量疹风险的百分比降低和获得的QALY.

主要成果:

在2年后,每个参与者的调整后的增量成本为87.45英,在没有湿疹的儿童比例中增加了很小,但不显著.
每个百分比减少湿疹风险的ICER为5337英;QALY显示微小的改善.
在5年后,软化剂组的成本较低,但无湿疹比例没有显著下降,ICER为3201英.

结论:

在婴儿期每天使用软化剂预防高风险儿童的湿疹,正如BEEP试验建议的那样,似乎没有成本效益.
这些发现表明,目前主动增强皮肤屏障的策略可能不会为预防湿疹提供有利的健康经济回报.

关键词:

亚托皮性湿疹是一种经济效益性经济效益性经济评估经济评价软化剂软化剂软化剂预防预防预防

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