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放射治疗前,期间和之后癌症患者疲劳的变化:元分析
Chia-Ling Li1, Pei-Ying Chen2, Tsui-Yun Yang3
1Department of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Worldviews on evidence-based nursing
|August 14, 2023
概括
放射治疗引起的疲劳 (RIF) 在癌症患者中很常见,治疗后可能持续超过三个月. 辐射治疗后,疲劳评估应持续很长时间,特别是对于前列腺癌患者和接受较高辐射剂量的患者.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 患者症状管理 患者症状管理
背景情况:
- 疲劳是癌症患者接受放射治疗时常见的,经常使人衰弱的症状.
- 以前的研究已经产生了不一致的发现,关于辐射疗法引起的疲劳 (RIF) 的轨迹和持续时间.
研究的目的:
- 系统地评估和量化癌症患者在放射治疗前,期间和之后疲劳水平的变化.
- 确定影响RIF模式和严重性的因素.
主要方法:
- 进行了一项全面的元分析,综合了2006年1月至2021年5月期间发表的65项研究的数据.
- 用标准化平均差异计算了即时,短期和长期疲劳变化的效应大小,并使用随机效应模型进行了组合.
- 使用子组分析和元回归来探索RIF的调节者.
主要成果:
- 在放射治疗后立即 (0.409),短期 (0.303) 和长期 (0.201) 观察到疲劳的显著加权平均效应大小.
- 与乳腺癌或其他癌症类型相比,前列腺癌患者的短期和长期疲劳效应较高.
- 较高的放射治疗剂量与增加的立即和短期疲劳有显著的关联.
结论:
- 放射治疗引起的疲劳 (RIF) 是一种持久的疾病,治疗后持续超过三个月.
- 对RIF的扩展评估至关重要,特别是对于前列腺癌患者和接受较高辐射剂量的患者.
- 建议在不同治疗阶段为疲劳管理制定量身定制的干预措施.
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