与艾滋病相关的卡波西肉瘤患者竞争风险的预后因素:基于SEER人口的SEER研究
Haili Wang1, Chengnan Guo2, Xin Zhang1
1Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
HIV medicine
|August 14, 2023
概括
竞争事件显著影响了获得性免疫缺陷综合征和卡波西综合征患者的生存率.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 获得性免疫缺陷综合征 (艾滋病) 患有卡波西肉瘤 (KS) 的患者的生存率改善,增加了对竞争死亡风险的关注.
- 了解KS特异性和非KS特异性死亡率的预后因素对于全面的患者管理至关重要.
研究的目的:
- 探索影响艾滋病相关KS (AIDS-KS) 患者的KS特异性和非KS特异性死亡率的预后因素.
- 开发和评估对艾滋病-KS患者竞争风险的预测性名录.
主要方法:
- 在1980-2016年期间使用SEER 18注册表对17103名被诊断为艾滋病-KS的成年患者进行了分析.
- 应用细分和灰色比例分布危险模型来确定预后因素.
- 构建和验证竞争性风险名ograms.
主要成果:
- 超过75%的患者死亡,其中15.50%归因于竞争事件.
- 老年 (>44岁) 增加了非KS死亡风险,但降低了KS死亡风险.
- 男性增加了KS死亡风险,但降低了非KS死亡风险.
- 与ART前的时代相比,抗逆转录病毒疗法 (ART) 时代与KS特异性和非KS特异性死亡率的风险降低有关.
结论:
- 竞争事件是艾滋病-KS患者生存的一个重要问题.
- 识别预后因素和利用预测工具,如名图,可以帮助改善患者的治疗结果.
- 进一步关注竞争风险是有必要的,以改善艾滋病-KS患者的预后.
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