药物和 Bruxism:在世界卫生组织的药物监测数据库中的研究
1Emeritus Professor of Medical and Clinical Pharmacology, Toulouse, France.
British journal of clinical pharmacology
|August 14, 2023
概括
一些抗抑郁药和抗精神病药与运动障碍布鲁克斯症有关. 这项研究表明,与抗抑郁药物相比,与北上腺素再吸收抑制的联系更强烈,而不是抗抑郁药物对血清素再吸收抑制的联系.
科学领域:
- 药物监督 药物监督 药物监督
- 运动障碍 运动障碍
- 神经科学是一个神经科学.
背景情况:
- Bruxism 是一种运动障碍,原因不明.
- 潜在的促成因素包括心理因素和药物.
- 药物诱导的 Bruxism 在临床实践中越来越令人担忧.
研究的目的:
- 为了调查药物暴露和 Bruxism 报告之间的潜在关联.
- 为了确定与 Bruxism 相关的特定药物类别和个人药物.
- 为了探索药物诱导的 Bruxism 背后的神经生物学机制.
主要方法:
- 使用了世界卫生组织 (WHO) 全球药监数据库Vigibase®.
- 在2000年至2022年期间对成年 Bruxism 报告进行了不成比例的分析.
- 计算报告几率比率 (ROR) 来评估毒品与布鲁克斯主义的关联.
主要成果:
- 鉴定了布鲁克西斯症与八种抗抑郁药物 (例如,塞特拉林,埃斯基塔洛普拉姆) 和四种抗精神病药物 (例如,齐普拉西,阿里皮普拉) 之间的关联.
- 检测到氧酸盐和美托克洛普拉胺的信号.
- 抗抑郁药物协会显示与上腺素载体 (NET) pKi有负相关性,但与上腺素载体 (SERT) pKi没有负相关性.
结论:
- 特定的抗抑郁药和抗精神病药与布鲁克斯症有关.
- 这些发现表明,在抗抑郁药诱导的 Bruxism 中,对 norepinephrine 再吸收的抑制可能比对 serotonin 再吸收的抑制发挥更重要的作用.
- 需要进一步的研究来阐明药物诱导的 Bruxism 的精确机制.
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