在患有下喉状状细胞癌的患者中,早期死亡的发生率和预测
Yujiao Li1,2,3,4,5, Chaosu Hu1,2,3,4,5
1Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China.
Ear, nose, & throat journal
|August 14, 2023
概括
早期死亡 (ED) 影响11.5%的下喉平细胞癌 (SCC) 患者,通常是由于癌症. 先进的年龄,阶段,转移和缺乏手术预测ED.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 低喉皮状细胞癌 (SCC) 在头部和部瘤学中构成了重大挑战.
- 早期死亡 (ED) 是癌症患者管理中的关键结果指标.
- 了解导致ED的因素对于改善患者存活率至关重要.
研究的目的:
- 确定被诊断为下喉平细胞癌 (SCC) 的患者早期死亡 (ED) 的发生率.
- 在这个患者群体中确定与早期死亡 (ED) 相关的人口和临床因素.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库用于跨越2004-2014年的患者数据.
- 计算了ED的速率,定义为存活时间小于或等于诊断后3个月.
- 使用后勤回归模型来评估与ED相关的风险因素.
主要成果:
- 分析了2659名下喉SCC患者,其中11.5%在3个月内经历ED.
- 特定于癌症的原因占过早死亡的79.2%.
- 勃起障碍的重要预测因素包括晚年,离婚/单身/寡妇 (DSW) 状态,非高加索族裔,高级T分类,远程转移,以及没有手术干预.
结论:
- 显著的比例 (11.5%) 的下喉SCC患者经历过早期死亡 (ED),主要是由于癌症特定原因 (79.2%).
- 勃起障碍的主要预测因素是晚年 (≥62岁),晚期T分类,远程转移和缺乏手术,未婚状态也是一个因素.
- 需要进一步研究更大的样本大小,以开发更好的预后和预测工具,以识别患有ED高风险的患者.
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