(II) 复杂浸的多孔纳米颗粒作为 Zn (II) 响应的"智能"MRI对比剂用于胰腺成像
Riya Mallik1, Muktashree Saha2, Vandna Singh3
1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039 Assam, India. cmukherjee@iitg.ac.in.
Journal of materials chemistry. B
|August 14, 2023
概括
研究人员开发了一种基于 (Mn(II)) 的新型MRI对比剂,封装在二氧化纳米颗粒中. 这种药物对 (Zn(II)) 离子有反应,显示了糖尿病中胰腺β细胞功能的非侵入性成像的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 医疗成像医学成像
背景情况:
- 1型和2型糖尿病是一种与胰腺β细胞功能相关的代谢障碍.
- (Zn(II)) 离子在β细胞对胰岛素的调节中起着至关重要的作用.
- 开发对Zn(II) 敏感的MRI对比剂对于非侵入性β细胞病理学评估至关重要.
研究的目的:
- 为了合成和表征一种基于Mn (II) 的新型MRI对比剂.
- 为了使二氧化纳米粒子具有Zn(II) 离子选择性部分的功能化.
- 评估开发的对比剂的Zn(II) 离子反应性和放松性.
主要方法:
- 在多孔的二氧化纳米圈中浸的七坐标Mn(II) 复合物的合成.
- 纳米球的表面功能化使用Py2Pic进行选择性Zn(II) 结合.
- 在存在不同度的Zn(II) 离子和牛血清白蛋白 (BSA) 的情况下测量放松性 (r1).
- 在体内MRI研究C57BL/6小鼠与葡萄糖刺激.
主要成果:
- 合成的复合物1@SiO2-Py2PicNP的r1放松度为13.19 mM-1 s-1.
- 在BSA的存在下,放松度增加到20.38mM-1s-1.
- 随着Zn(II) 离子度的增加,观察到r1的线性增加,达到39.01mM-1s-1.
- 在体内MRI显示,在药物和葡萄糖刺激剂后,胰腺的对比度增强.
结论:
- 开发的基于Mn2的纳米粒子是一个有前途的Zn2响应的MRI对比剂.
- 该药物显示了胰腺β细胞功能的非侵入性成像潜力.
- 这项技术可以帮助诊断和监测糖尿病.
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