软化剂"Plus"在轻微的无氧性皮肤炎中短期和长期都有好处
Silmara Cestari1, Priscila Correia2, Delphine Kerob3
1Department of Dermatology, Sírio Libanês Hospital, São Paulo, Brazil.
Clinical, cosmetic and investigational dermatology
|August 14, 2023
概括
这项研究发现,Emollient+在28天内显著改善了轻微的亚托皮炎 (AD) 症状,皮肤水分和生活质量. 所有年龄段的参与者都能很好地忍受这种药剂.
科学领域:
- 皮肤病学 皮肤病学
- 临床研究 临床研究
- 皮肤健康 皮肤健康
背景情况:
- 无氧性皮肤炎 (AD) 是一种慢性炎症性皮肤疾病,其特点是皮肤屏障功能受损,微生物组失调和炎症.
- 目前对阿尔茨海默病的治疗通常包括软化剂,以支持健康的皮肤微生物群,并控制疾病的严重程度.
研究的目的:
- 在168天的时间内,评估一种新型轻度乳液Emollient+在患有轻度亚托皮炎的受试者身上的疗效和耐受性.
- 软化剂+ 含有维生素E,托科菲罗尔,甘油,水 filiformis,和microresyl.
主要方法:
- 一项开放性研究包括56名受试者 (年龄大于3岁) 患有轻度,稳定的AD (SCORAD <25) 至少6个月.
- 评估包括SCORAD,爆发频率,临床迹象/症状,皮肤水分 (角膜计),局部耐受性和通过DLQI/CDLQI在基线和多次随访至D168.8的DLQI/CDLQI的生活质量 (QoL).
- 试验对象每天至少使用一次Emollient+.
主要成果:
- 在大多数临床参数中,D28观察到显著的改善 (p <0.05),除了儿童的红外.
- 通过D168,SCORAD,临床迹象/症状,发作频率,皮肤水分和QoL,与所有人群 (全球,成人,儿科) 的基线相比,显著改善 (p <0.05).
- 软化剂+疗法表现出极好的局部耐受性.
结论:
- 软化剂+对于管理轻度的亚托皮性皮肤炎是非常有益的,并且耐受性很好.
- 在阿尔茨海默病的迹象,症状,皮肤水分和生活质量方面,早在D28.8时就已经注意到了早期的改善.
- 这项研究支持使用Emollient+作为轻度AD的有效治疗选择.
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