沉重金属和微量元素在膀癌中的关联:一项病例对照研究
Sridhar Panaiyadiyan1, Javed Ahsan Quadri2, Brusabhanu Nayak1
1Department of Urology, All India Institute of Medical Sciences, New Delhi, India.
概括
暴露于重金属,包括,和,与更高的膀癌症风险有关. 这些金属破坏新陈代谢并增加氧化应激,患者的抗氧化剂水平较低和脂质过氧化率较高表明了这一点.
科学领域:
- 环境毒理学环境毒理学
- 在瘤学瘤学.
- 生物化学 生物化学
背景情况:
- 异常的重金属 (HM) 和微量元素 (TE) 含量可以破坏新陈代谢并导致致癌.
- 膀癌 (CAUB) 是一个重要的健康问题,环境因素的作用,如HM和TE需要进一步调查.
研究的目的:
- 评估血液和尿液中特定重金属和微量元素与尿道膀癌 (CAUB) 之间的关联.
- 与健康对照组相比,评估CAUB患者的还氧化状态,包括谷氨过氧化酶 (GSH-Px),超氧化脱氧化酶 (SOD) 和脂质过氧化酶 (LPO).
主要方法:
- 一项比较研究涉及100名经过活检证明的CAUB患者和100名年龄和性别匹配的健康对照.
- 对血液和尿液样本进行 (As),铜 (Cu), (Mn), (Se), (Cd), (Pb) 和 (Hg) 的水平分析.
- 评估血清GSH-Px,SOD和LPO水平,以确定氧化应激标志物.
主要成果:
- 与对照组相比,CAUB患者的血液和尿液中As,Mn和Pb水平显著更高.
- 在CAUB患者中观察到血中Se水平显著降低.
- CAUB病例显示血清GSH-Px和SOD水平较低,血清LPO水平较高,表明氧化应激增加.
结论:
- 血液和尿液中As,Mn和Pb度的升高与CAUB有显著的关联.
- 在CAUB患者中,抗氧化剂 (GSH-Px,SOD) 的水平降低和脂质过氧化增加表明氧化应激在疾病发病过程中发挥了作用.
- 这些发现突显了重金属暴露对尿道膀癌症发生的潜在影响.
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