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系统性疾病和胃肠道癌症的风险
Naila Malkani1, Muhammad Usman Rashid2
1Department of Zoology, Government College University, Lahore, Punjab, Pakistan.
Journal of cancer & allied specialties
|August 14, 2023
概括
没有治疗的全身性疾病,如糖尿病和高血压,可以增加胃肠道 (GI) 癌症的风险. 本综述探讨了慢性疾病和胃肠道癌症发展之间的联系,突出了关键机制.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 胃肠道 (GI) 癌症对全球健康构成重大负担,是全球癌症死亡的第二大原因.
- 胃肠道癌的危险因素包括生活方式选择,感染和遗传倾向,慢性系统性疾病的显著贡献.
- 系统性疾病可以引发慢性炎症和氧化应激,创造有利于胃肠道癌症发展的微环境.
研究的目的:
- 审查未经治疗的全身性疾病与胃肠道癌症的发展之间的关联.
- 阐明系统性疾病对肠道癌症产生有助的潜在机制.
- 突出管理肠道癌症预防的系统性条件的重要性.
主要方法:
- 关于研究系统性疾病和肠道癌症之间的联系的文献综述.
- 分析拟议的生物途径,包括氧化应激,炎症和遗传变化.
- 综合有关特定系统性疾病 (如糖尿病,肝炎,高血压) 和其致癌潜力的证据.
主要成果:
- 糖尿病,肝炎,获得性免疫缺陷综合征,和高血压等未经治疗的全身性疾病被确定为肠胃癌的潜在前体.
- 这些疾病通过涉及氧化应激,慢性炎症和遗传突变的机制促进胃肠道癌发生.
- 系统性疾病的长期存在在肠道中创造了一个支持瘤的环境.
结论:
- 系统性疾病的有效管理和治疗对于减少肠胃癌的发病率至关重要.
- 了解全身健康和肠道癌之间的机制联系,为新的预防和治疗策略提供了目标.
- 本次审查强调了系统健康和肠道癌症风险的相互联系,强调了整体的疾病管理方法.
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