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Updated: Aug 7, 2026

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scDual-Seq对Toxoplasma gondii感染的小鼠的BMDCs揭示了异质性和不同的感染动态

Franziska Hildebrandt1, Mubasher Mohammed1, Alexis Dziedziech1,2

  • 1Department of Molecular Biosciences, The Wenner Gren Institute, Stockholm University, Stockholm, Sweden.

Frontiers in immunology
|August 14, 2023
PubMed
概括

毒素虫寄生虫操纵树突细胞的不同亚群,揭示了对宿主-病原体相互作用的新见解. 这项研究提供了一个高分辨率的资源,以了解对感染的免疫反应.

关键词:
这些BMDC是BMDC.双重单细胞RNA-seq.这种毒性淋巴细胞 (Toxoplasma gondii) 是来自骨髓的树突细胞.主体-病原体相互作用免疫调节的免疫调节这就是 scDual-Seq.

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Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...