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内皮活化与压力指数之间的关联和菌性ICU患者的28天死亡率:一个回顾性队列研究

Hong-Bo Xu^1,2, Yuan Ye^1,2, Fang Xue^1,2

¹Department of Critical Care Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen 518033, China.

International journal of medical sciences

|August 14, 2023

概括

内皮激活和压力指数 (EASIX) 与败血症患者的不良结果有关. 较高的EASIX分数表明,败血症幸存者在28天和90天内死亡的风险更高.

科学领域:

生物标志物生物标志物
关键护理医学关键护理医学
病理生理学病理生理学

背景情况:

内皮功能障碍在败血症中起着关键作用.
内皮激活和压力指数 (EASIX) 作为内皮功能障碍的生物标志物.
在败血症中EASIX的预后价值需要进一步调查.

研究的目的:

为了研究EASIX和毒症患者的预后之间的关联.
评估EASIX作为败血症患者死亡率的预测指标.

主要方法:

来自MIMIC-IV数据库的数据被追溯分析.
使用乳酸脱酶,肌素和血小板计数来计算EASIX分数.
根据日志2转换的EASIX,患者被分为三分层,并进行生存分析.

主要成果:

较高的EASIX分数与28天和90天死亡率的增加显著相关.
高EASIX三位体患者的生存率较低.
观察到EASIX水平与死亡风险之间存在线性关系.

结论:

升高的EASIX是败血症患者死亡率的重要预测因素.
在败血症管理中,EASIX可以被用作预后生物标志物.
进一步的研究可能会探索针对败血症内皮细胞激活的治疗干预措施.

关键词:

内皮细胞激活和压力指数这就是MIMIC-IV.它们的内皮质 (endothelium).死亡率死亡率这是一种血症.

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