大脑氨酸-氨酸系统:从生理学到病理学在由SARS-CoV-2诱导的神经元并发症
Shamseddin Ahmadi1, Shiler Khaledi1
1Department of Biological Science, Faculty of Science, University of Kurdistan, Sanandaj, Iran.
Analytical cellular pathology (Amsterdam)
|August 14, 2023
概括
严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染通过改变大脑影响中枢神经系统 (CNS).
科学领域:
- 神经科学是一个神经科学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 氨酸- ангиотензин系统 (RAS) 酶,氨酸转化酶2 (ACE2),存在于中枢神经系统 (CNS).
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 利用ACE2进入细胞,引发了人们对中枢神经系统病毒感染和神经系统并发症的担忧.
- 在2019年冠状病毒病 (COVID-19) 患者中,经常报告神经症状.
研究的目的:
- 审查大脑RAS组件,特别是ACE2在COVID-19引起的神经并发症中的作用.
- 更新对SARS-CoV-2对中枢神经系统的影响的理解.
主要方法:
- 审查有关SARS-CoV-2,ACE2,RAS和神经系统并发症的现有文献.
- 对SARS-CoV-2进入大脑的拟议路线的分析.
- 检查RAS变化与神经症状之间的联系.
主要成果:
- SARS-CoV-2 可以通过嗅觉,血液或逆行轴突路径进入大脑.
- 常见的神经症状包括头痛,厌氧和肌痛;严重的结果包括脑血管疾病和认知障碍.
- 通过SARS-CoV-2降低大脑ACE2的调节,增加了血管激素II (Ang II) 水平,导致高炎症,氧化应激和神经退行.
结论:
- 大脑RAS组件的变化,特别是ACE2,有助于COVID-19的神经表现.
- 在下丘脑中降低ACE2的调节可以引发焦虑和压力反应.
- SARS-CoV-2 感染可能会破坏中枢神经系统的神经传输的调节,加剧神经系统并发症.
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