饮食因素与结直肠状息肉之间的关联:系统性审查和元分析
Zhixin Zhu1, Xifei Guan1, Nawen Liu1
1Department of Big Data in Health Science, and Center for Clinical Big Data and Statistics, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Frontiers in nutrition
|August 14, 2023
概括
食纤维摄入量可以防止结直肠状多体 (SP),而红肉消费会增加SP风险. 这一元分析强调了SP预防策略的关键饮食因素.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 预防医学 预防医学
背景情况:
- 饮食因素与结直肠状息肉 (SP) 的发展有关.
- 关于饮食和SPs的流行病学证据是不一致的.
- 需要进行系统审查和元分析来澄清这些关联.
研究的目的:
- 系统地审查和元分析饮食因素对结直肠状息肉 (SP) 的影响.
- 确定影响SP风险的特定饮食成分.
主要方法:
- 在PubMed,Cochrane,Embase和CNKI数据库中进行全面的文献搜索,直到2023年2月27日.
- 包括28项符合条件的研究,研究饮食因素与SPs之间的关联.
- 随机效应模型元分析以计算聚合几率比率 (OR) 和95%置信区间 (95% CI).
主要成果:
- 较高的食纤维摄入量与SPs风险降低有关 (OR = 0.90,95% CI:0.82-0.99).
- 红肉摄入量显著增加了SP风险 (OR = 1.30,95% CI: 1.13-1.51).
- 维生素D和与整体SP风险没有显著关联,尽管维生素D摄入量与特定SP类型 (SSA/P) 的风险降低有关. 叶酸摄入量与高可塑性息肉 (HPs) 的风险降低有关.
结论:
- 增加食纤维摄入量是对结直肠状息肉 (SP) 的保护因素.
- 红肉消费与患SPs的风险更高有关.
- 饮食修改,特别是增加纤维和限制红肉,可以为SP预防策略提供信息.
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