Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Clinical Trials01:16

Clinical Trials

6.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
6.9K
Clinical Trials: Overview01:11

Clinical Trials: Overview

3.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.0K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

148
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
148
Blinding01:11

Blinding

2.5K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
2.5K
Case Studies01:22

Case Studies

11.7K
There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
11.7K
Operant Conditioning Intervention01:24

Operant Conditioning Intervention

81
Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
81

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Correction to: 2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/ SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Circulation·2026
Same author

Intravascular imaging guidance for percutaneous coronary intervention and clinical outcomes: meta-analyses of randomized controlled trials.

Cardiovascular intervention and therapeutics·2026
Same author

Outcomes of Percutaneous and Surgical Interventions of Right-Sided Heart Masses in Older Patients: A Nationwide Comparative Study.

Journal of the American Heart Association·2026
Same author

Direct Oral Anticoagulant Monotherapy Reduces Mortality in Patients with Atrial Fibrillation and Stable Coronary Artery Disease.

Mayo Clinic proceedings·2026
Same author

Comparative effectiveness of drug-coated and uncoated balloon angioplasty in dysfunctional hemodialysis circuits among Medicare beneficiaries.

Journal of vascular surgery·2026
Same author

Saddle pulmonary embolism with acute cor pulmonale in contemporary practice: Epidemiological trends and reperfusion strategies.

Vascular medicine (London, England)·2026

相关实验视频

Updated: Jul 19, 2025

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring
08:45

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring

Published on: November 13, 2012

13.8K

在临床实践中对BEST-CLI试验结果进行上下文化

Neel M Butala1, Venita Chandra2, Joshua A Beckman3

  • 1Division of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.

Journal of the Society for Cardiovascular Angiography & Interventions
|August 14, 2023
PubMed
概括

这就是BEST-CLI试验.

关键词:
慢性四肢威胁性缺血症是什么这是内血管内血管的内血管.结果就是结果.重新血管化的过程.

更多相关视频

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.7K
Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.1K

相关实验视频

Last Updated: Jul 19, 2025

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring
08:45

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring

Published on: November 13, 2012

13.8K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.7K
Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.1K

科学领域:

  • 血管外科 血管外科
  • 干预心脏病学 干预心脏病学
  • 医疗保健服务研究 医疗服务研究

背景情况:

  • 慢性四肢威胁性缺血症 (CLTI) 带来了重大的长期挑战.
  • 对CLTI的最佳再血管化策略仍在调查中.
  • 需要对BEST-CLI试验对更广泛的CLTI群体的通用性进行评估.

研究的目的:

  • 评估BEST-CLI试验结果对具有CLTI的医疗保险受益人的概括性.
  • 为了比较现实世界医疗保险人口中的重血管化结果与BEST-CLI试验队列.
  • 为了评估内血管和外科手术重血管化的有效性,在老年人与CLTI.

主要方法:

  • 对接受重血管化治疗的CLTI医疗保险受益者 (65-85岁) 的回顾性分析 (2016-2019).
  • 主要暴露:内血管再血管化 vs. 自体 vs.非自体移植.
  • 主要结局:主要不良肢体事件 (MALE) 和死亡的组合.

主要成果:

  • 医疗保险队列比BEST-CLI试验参与者更老,更女性,并患有更多的并发病.
  • 与BEST-CLI相比,在医疗保险队列中,手术重血管化时,死亡或MALE的原始风险更高.
  • 与BEST-CLI试验相比,Medicare队列中的内血管治疗显示出类似的死亡或MALE风险,但重大干预风险明显较低.

结论:

  • 贝斯特-CLI试验的结果可能不能完全代表整个医疗保险人口的结果.
  • 在患有CLTI的医疗保险受益人中,手术重血管化的现实结果似乎比BEST-CLI试验更糟糕.
  • 与试验数据相比,内血管再血管化在医疗保险人群中表现出有利的结果,特别是在重大干预方面.