欧米茄-3指数作为精神疾病的风险因素:一个叙事性审查
Helena Sofia Antao1, Ema Sacadura-Leite1,2,3, Narcisa Maria Bandarra4
1Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
Frontiers in psychiatry
|August 14, 2023
概括
欧米茄-3指数是红细胞中EPA和DHA的度量,与心理健康状况有关. 较低的欧米茄-3指数水平可能表明患重度抑郁症,产后抑郁症,精神病和痴呆症的风险增加.
科学领域:
- 营养精神病学 营养精神病学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 代表红细胞EPA和DHA水平的omega-3指数与各种心理健康状况有关.
- 然而,关于风险分层或心理健康中的omega-3指数目标值的共识仍然难以达成.
研究的目的:
- 系统地审查有关omega-3指数与精神疾病之间的联系的现有文献.
- 在特定的精神疾病中提出omega-3指数的潜在风险值.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中进行了全面的文献搜索.
- 选择了相关的英语原创研究,搜索和选择过程遵循PRISMA指南.
- 包括36项研究,调查与产后抑郁症,严重抑郁症,双相情感障碍,精神分裂症,精神病和痴呆症相关的omega-3指数.
主要成果:
- 在36项审查的研究中,有30项表明患者组和对照组之间的omega-3指数有显著差异,或omega-3指数与疾病严重程度之间的反向关系.
- 有证据表明,omega-3指数是严重抑郁症,产后抑郁症,精神病和痴呆症的潜在危险因素.
结论:
- 欧米茄-3指数是一个令人信服的生物标志物,与几种心理健康状况相关.
- 西方人群提出的风险值包括:大抑郁症和痴呆症的4-5%,产后抑郁症的5%和精神病过渡的4%.
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