在新发作的战斗相关的创伤后应激障碍中补充孟坦丁的效果核心症状:试点研究
Fatemeh Rajabi1, Fatemeh Fozveh1, Mohammad Reza Maracy2
1Department of Psychiatry, Isfahan University of Medical Sciences, Isfahan, Iran.
Iranian journal of psychiatry
|August 14, 2023
概括
记忆剂治疗显著减少了军事人员的PTSD症状. 这项研究表明,记忆素是与战斗有关的创伤后应激障碍 (PTSD) 的有效补充疗法.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 标准的神经心理测试揭示了创伤后应激障碍 (PTSD) 患者的记忆缺陷.
- 与战斗相关的PTSD在军事人口中提出了独特的挑战.
- 现有的PTSD治疗方法可能有局限性,需要新的治疗方法.
研究的目的:
- 评估记忆素作为军人中与战斗有关的PTSD新病例的辅助治疗的疗效和安全性.
- 在16周的时间内评估孟坦丁对PTSD症状严重性的影响.
- 为与战斗相关的PTSD提供潜在管理策略的见解.
主要方法:
- 进行了一项为期16周的前性,双盲,随机对照试验.
- 招募了26名具有新的战斗相关PTSD (DSM-5标准) 的军人.
- 参与者除了服用现有的药物外,还接受了孟坦丁 (定位为每天20毫克) 或安慰剂.
主要成果:
- 与安慰剂组相比,记忆素组的临床医生管理的PTSD评分 (CAPS) 平均得分显著下降 (P = 0.006).
- 从基线到第16周,在记忆剂组中观察到平均CAPS总得分的显著降低 (P < 0.001).
- 最初在基线和第8周的组之间没有观察到CAPS得分的显著差异,但在第16周出现了显著下降.
结论:
- 补充记忆素在减轻退伍军人患者PTSD症状严重程度方面表现出有效性.
- 这些发现表明,美曼丁是一种潜在的有价值的治疗选择,用于管理与战斗有关的PTSD的新病例.
- 这项研究为军事人口中PTSD的临床管理提供了有价值的数据.
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