在COVID-19中使用非标签药物:基于跨部门观察研究的临床医生的看法
1Department of Pharmacology, Himalayan Institute of Medical Sciences, Dehradun, IND.
Cureus
|August 14, 2023
概括
在印度的第二次COVID-19浪潮期间,由于指南混乱和证据有限,医生广泛使用非标签药物 (OfLDs). 许多人认为他们的使用是不道德的,通常是由同行建议或压力驱动的.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在印度的第二次COVID-19浪潮期间,缺乏统一的国家治疗指南导致了多样化的治疗策略.
- 使用非标签药物 (OfLDs) 成为一种常见的,但尚未标准化的方法.
研究的目的:
- 为了确定治疗COVID-19患者的医生对OfLD处方的流行率.
- 评估医生对OfLD使用的适当性和道德性的看法.
- 确定影响使用OfLDs的决定的因素.
主要方法:
- 在印度Uttarakhand的医生中进行了一项基于网络的横截面调查,这些医生在第二波期间治疗了COVID-19患者.
- 数据采集使用经过验证的问卷,最低样本大小为370名参与者.
- 统计分析涉及描述和分析方法来解释收集的数据.
主要成果:
- 在419名受访者中,有90.7%的受访者表示使用了OfLD,其中62.5%的人认为它们是有益的.
- 只有34.1%的人认为OfLD的使用是道德上的,而20%的人在胁迫下开处方.
- 使用的原因包括个人信念,同行建议,以及因相互矛盾的指导方针而引起的困惑.
结论:
- 该研究强调了COVID-19大流行期间印度广泛使用OfLDs,通常是由不确定性和各种证据驱动的.
- 处方实践受到超出科学共识的因素的影响,包括外部压力.
- 需要更明确的国家指导方针,以确保在公共卫生危机期间提供标准化和基于证据的治疗.
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