在关键四肢缺血症中使用干细胞治疗
Madhan Jeyaraman1,2,3,4,5, Somumurthy Nagarajan6, Nicola Maffulli7,8,9,10
1Orthopaedics, ACS Medical College and Hospital, Dr. MGR Educational and Research Institute, Chennai, IND.
Cureus
|August 14, 2023
概括
干细胞治疗 (SCT) 为关键四肢缺血症 (CLI) 提供了一个有前途的非手术选择,改善血液流动并减少截肢率. 这种疗法提高了无截肢生存率和肢体输液,即使在无法接受传统治疗的患者中也是如此.
科学领域:
- 再生医学是一种再生医学.
- 血管生物学 血管生物学
- 细胞疗法细胞疗法
背景情况:
- 关键四肢缺血症 (CLI) 是外周动脉疾病的严重并发症,通常导致截肢和高经济成本等不良结果.
- 现有的CLI治疗方法往往不令人满意,特别是在糖尿病和动脉样硬化患者中,因为血管健康受到损害.
- 手术干预可以进一步增加CLI患者的血管损伤和截肢率.
研究的目的:
- 评估干细胞治疗 (SCT) 作为关键四肢缺血症 (CLI) 的非手术治疗的疗效.
- 评估SCT在促进血管生成和改善缺血四肢 perfusion 的潜力.
- 确定SCT对CLI截肢率和患者存活率的影响.
主要方法:
- 在主要数据库 (PubMed,SCOPUS,EMBASE,ScienceDirect) 进行了全面的文献搜索,寻找临床试验和关于CLI中SCT的研究.
- 最初的搜索产生了2391个结果,在删除重复结果后,改进到565个结果.
- 45篇文章的全文综述,最终根据独特的结果选择了25项相关研究.
主要成果:
- 干细胞疗法 (SCT) 在关键四肢缺血症 (CLI) 中有效促进动脉发生和新血管化.
- 骨髓衍生中细胞显著降低了发病率,改善了无截肢生存率 (AFS).
- SCT导致远端输液增强和改善结果,即使在"没有选择"的CLI患者中,不适合传统疗法.
结论:
- 干细胞疗法 (SCT) 是关键四肢缺血症 (CLI) 的可行和有前途的治疗方法,特别是对于传统选择有限的患者.
- 在CLI患者中,SCT显著改善了无截肢生存率 (AFS),远端输液,步行距离和整体生存率.
- 该疗法耐受性良好,并提供了一种潜在的解决方案,以减少与CLI相关的发病率和经济负担.
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