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体的蛋白质效应:对蛋白质稳定和大脑蛋白质病变的影响

Lizbeth García-Velázquez¹, Lourdes Massieu¹

¹Department of Molecular Neuropathology, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México (UNAM), México City, Mexico.

Frontiers in molecular neuroscience

|August 14, 2023

概括

体,如β-基酸盐 (BHB),通过影响蛋白质调节和平衡,为神经退行性疾病提供治疗潜力. BHB影响细胞过程,并可能在阿尔茨海默氏症和帕金森病等疾病中对抗蛋白质聚合.

科学领域:

生物化学生物化学
细胞生物学细胞生物学
神经科学是一个神经科学.

背景情况:

体 (KBs),包括β-基酸盐 (BHB),因其生理益处和治疗潜力越来越受认可,特别是在神经退行性疾病中.
BHB 作为一种替代能源,除了提供能量之外,还发挥了监管功能,影响细胞蛋白质组.
性饮食 (KD) 促进了KB的产生,促进了它们在大脑中的利用.

研究的目的:

审查关于体对蛋白质构成和蛋白质静止的影响的当前文献.
探索BHB诱导的修饰对神经退行性疾病 (如阿尔茨海默氏症和帕金森病) 的潜在影响.

主要方法:

对调查体,β-基基化 (Kbhb) 和蛋白质稳定性的研究进行的文献综述.
对Kbhb在细胞信号传递,基因组调节和蛋白质平衡途径 (如UPR和自) 中的作用的研究分析.
检查证据,将基因饮食和BHB治疗与阿尔茨海默氏症和帕金森病模型的结果联系起来.

主要成果:

BHB可以形成一种新的翻译后修饰,β-基基化 (Kbhb),影响参与染色质结构,DNA修复,转录和新陈代谢的蛋白质.
基因基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因表达基因.
BHB调节未折叠蛋白质反应 (UPR) 并刺激自,增强蛋白质稳态,并可能减轻蛋白质聚合.

结论:

体,特别是BHB,在调节细胞蛋白质组和通过Kbhb和调节UPR和自等机制维持蛋白质平衡方面发挥着重要作用.
这些发现表明,BHB对蛋白质稳定性的影响可能是基因饮食和BHB治疗在阿尔茨海默氏症和帕金森病等神经退行性疾病中所观察到的益处的基础.
对Kbhb和BHB对细胞信号和基因组调节的影响的进一步研究可能会揭示蛋白质病变的新疗法策略.

关键词:

自自是自的过程.大脑蛋白质病变大脑蛋白质病变体是指体中的体.蛋白质组适应的适应性不折叠的蛋白质反应反应在β-hydroxybutyrate中使用.这是一种β-hydroxybutyrylation.

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