在与癌症相关的疲劳中增加后带带皮质血液流动
David Raizen1,2,3, Rupal Bhavsar1,3, Brendan T Keenan2,3
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Frontiers in neurology
|August 14, 2023
概括
接受放射治疗的癌症患者表现出大脑血液流量改变后带皮质皮质,这是默认模式网络的关键部分. 这种变化可能表明驱动癌症相关疲劳进展的独特机制.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 与癌症相关的疲劳 (CRF) 是癌症治疗后的一个普遍和衰弱的症状.
- 大脑的机制和CRF的进展仍然不太清楚.
- 之前的研究表明,默认模式网络 (DMN) 导致疲劳.
研究的目的:
- 研究与健康对照组 (HC) 相比,接受放射治疗 (RAT) 的癌症患者的DMN枢纽后带皮层 (PCC) 中的大脑血流 (CBF) 差异.
- 在CRF中探索PCC CBF,疲劳和认知任务表现之间的关系.
- 评估PCC CBF在CRF进展和治疗后恢复期间的变化.
主要方法:
- 使用动脉旋转标记 (ASL) perfusion 功能磁共振成像 (fMRI).
- 在PCC中,休息状态CBF在16名癌症患者 (前列腺/乳腺) 和18名HC患者之间进行了比较.
- 在疲劳性精神运动警觉任务 (PVT) 之前和之后测量CBF.
主要成果:
- 与HC相比,癌症患者在PCC中显著增加了静止CBF.
- 在RAT后的随访期内,PCC CBF的升高在患者中持续存在.
- 在PVT后的PCC CBF变化与疲劳变化相关,这表明与CRF恢复有联系.
结论:
- 用RAT治疗的癌症患者在PCC静止CBF中表现出明显的改变.
- 这些PCC CBF变化与癌症相关的疲劳有关,并且可能在治疗后持续存在.
- 经过认知挑战后的PCC CBF可以作为CRF恢复的潜在生物标志物.
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