饮食中的蛋白质摄入量会影响尿与临床相关抑郁症之间的关联:NHANES 2007-2018年的证据
Xue Kong1, Xia Shen2, Long Yang3
1Department of Laboratory Medicine The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University Wuxi China.
Food science & nutrition
|August 14, 2023
概括
高蛋白摄入量与较低的尿度相结合,可能会降低抑郁症的风险. 这一发现表明了管理临床相关抑郁症 (CRD) 的潜在饮食策略.
科学领域:
- 营养流行病学 营养流行病学
- 公共卫生 营养 公共卫生 营养
- 心理健康研究 心理健康研究
背景情况:
- 度和蛋白质摄入量是潜在影响抑郁症状的关键营养因素.
- 现有的研究缺乏对蛋白质摄入量如何改变水平与抑郁风险之间的关联的研究.
研究的目的:
- 研究尿度 (UIC) 与临床相关抑郁症 (CRD) 风险之间的关系.
- 专门在不同蛋白质摄入类别中探索这种关系.
主要方法:
- 来自国家健康和营养检查调查 (2007-2018) 的大型横截面数据集 (N=10,462) 的分析.
- 使用患者健康问卷 (PHQ-9) 评估CRD.
- 通过使用ICP-MS测量24小时饮食回忆和UIC的蛋白质摄入量;统计分析包括后勤回归和限制性立方线.
主要成果:
- 在对混因子进行调整后,在较高的UIC和CRD风险之间发现了正相关性 (OR:1.36).
- 低UIC (<100μg/L) 与高蛋白摄入量 (OR:0.73) 个体的CRD患病率较低有关,但与低蛋白摄入量个体无关.
- 限制性立方线线表明,在低蛋白组中,UIC和CRD之间存在接近L形的关系,而在高蛋白组中则存在线性关系.
结论:
- 蛋白质摄入量显著调节尿度与临床相关抑郁症风险之间的关联.
- 将足够的蛋白质摄入量与足够的水平相结合,可能是减少CRD患病率的有益策略.
- 这些发现为通过饮食干预来管理抑郁症提供了潜在的临床影响.
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