补充微封装益生菌调节肠道健康和肠道微生物群
Ishwari Gyawali1, Guilian Zhou2, Guli Xu1
1Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science South China Agricultural University Guangzhou China.
Food science & nutrition
|August 14, 2023
概括
在聚烯酸盐树脂中封装Lactobacillus paracasei益生菌显著提高了它们的生存和有效性. 这种微封装改善了肠道屏障功能,减少了炎症,并提高了小鼠的抗氧化能力.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 生物技术是生物技术.
背景情况:
- 益生菌提供健康益处,但在胃过境期间生存能力较差.
- 胃酸,酶和胆汁盐会降解敏感的益生菌物种,如乳杆菌.
- 封装是一种保护益生菌免受严重胃肠道疾病的策略.
研究的目的:
- 评估包装在聚烯酸盐树脂中的Lactobacillus paracasei在改善肠道健康方面的有效性.
- 评估微封装对益生菌生存能力和宿主生理反应的影响.
- 研究对肠道屏障功能,炎症,微生物群和抗氧化剂状况的影响.
主要方法:
- 使用聚烯酸盐树脂封装了Lactobacillus paracasei.
- C57BL/6雄性小鼠被分为控制,未封装益生菌和封装益生菌组.
- 小鼠被食各自的饮食4周,然后对便和肠道参数进行分析.
主要成果:
- 封装的益生菌显著增加了便的水分,的高度与密室深度的比率,以及肠道粘素/sIgA.
- 微封装通过上调MUC-2和紧结蛋白来增强肠道屏障功能.
- 促炎因素减少,而抗炎因素增加;抗氧化能力改善 (增加GSH-Px,TAOC;减少MDA).
- 便中的LPS下调,有益的代谢物 (乙酸,乳酸) 增加,乳酸菌的比例显著更高.
结论:
- 聚烯酸树脂微封装有效地保护Lactobacillus paracasei,增强其对宿主肠道健康的有益作用.
- 微封装改善了肠道屏障的完整性,调节了免疫反应,并增强了抗氧化剂防御.
- 这种方法为有效地将益生菌输送到肠道提供了一个有希望的策略.
关键词:
牛乳杆菌 帕拉凯西 (Lactobacillus paracasei) 是一种植物.肠道健康 肠道健康鼠标 鼠标 鼠标 鼠标我们的微生物群.微封装的方法是微封装.聚烯酸盐树脂是一种多烯酸盐树脂.更多相关视频
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