通过对多变量因素的人工智能分析来预测COVID-19的严重程度
Yu Fu1, Lijiao Zeng1, Pilai Huang1
1Department of Infectious Diseases, Department of Thoracic Surgery, Department of Radiology, National Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen Third People's Hospital, Shenzhen, China.
Heliyon
|August 14, 2023
概括
这项研究开发了一个使用CT扫描和生物标志物的AI模型来预测严重的COVID-19. 该模型准确识别高风险患者,有助于早期治疗决策,以获得更好的结果.
科学领域:
- 医疗成像医学成像
- 人工智能的人工智能
- 流行病学 流行病学
背景情况:
- COVID-19进展至严重疾病是死亡的一个重要原因.
- 对严重的COVID-19的预测模型对于及时的患者管理至关重要.
- 早期识别有风险的患者可以指导治疗策略,提高生存率.
研究的目的:
- 开发和验证一个多变量生存模型来预测严重的COVID-19发病.
- 将早期CT成像与生理指标和生物标志物相结合,以提高预测.
- 评估住院成年患者中严重COVID-19进展的风险.
主要方法:
- 对338名成年COVID-19患者的回顾性招生.
- 基于人工智能的多变量生存模型的开发.
- 早期CT图像,生理指标和生物标志物的分析.
主要成果:
- 确定了关键的危险因素:年龄,BMI,发烧,高血压和糖尿病.
- 严重的COVID-19病例显示器官功能,炎症,氧化和凝血生物标志物的早期异常.
- 综合模型实现了高预测性能 (平均时间依赖的AUC=0.880).
结论:
- 结合CT图像和生物标志物的多变异性生存模型显示,预测严重的COVID-19有很大的潜力.
- 早期预测可以为患有严重疾病风险的患者提供及时的临床干预.
- 医疗数据的AI驱动分析可以提高传染病的预后准确性.
相关概念视频
01:18Steps in Outbreak Investigation
152
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
152
01:18Factors Affecting Illness
4.3K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.3K
01:03Prediction Intervals
2.3K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
2.3K
01:29Issues And Trends In Healthcare Delivery System
5.7K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.7K
01:17Classification of Illness
7.6K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
7.6K
01:05Single Nucleotide Polymorphisms-SNPs
15.3K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.3K