身体活动与高风险高血压患者的临床结果之间的关联:SPRINT后期分析
Richard Kazibwe1, Matthew J Singleton2, Parag A Chevli1
1Department of Medicine, Section on Hospital Medicine, Wake Forest University School of Medicine, 1 Medical Center Blvd, Winston-Salem, NC 27157, USA.
每月一次进行强烈体力活动 (PA) 或每天15分钟进行中等强度PA,可显著降低高风险高血压患者心血管事件的风险. 强烈的PA还可以降低所有原因的死亡风险.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 运动生理学 运动生理学
背景情况:
- 身体活动 (PA) 对于管理高血压,降低发病率和死亡率至关重要.
- 在高风险高血压人群中,PA对临床结果的具体影响仍未得到充分研究.
研究的目的:
- 研究高风险高血压患者体力活动水平与临床结果之间的关联.
- 分析SPRINT试验中强烈强度PA (VPA) 和中度强度PA (MPA) 与心血管事件和全因死亡率之间的关系.
主要方法:
- 利用了来自8,320名SPRINT参与者的自我报告的基线PA数据.
- 按频率分类VPA (≥1次/月对比很少/从未) 和按持续时间分类MPA (≥15分钟/天对比<15分钟/天).
- 采用多变量考克斯回归来评估与主要复合结果 (心血管事件) 和全因死亡率的关联.
主要成果:
- VPA (≥1次/月) 与主要结局 (HR 0.79),心肌梗塞 (HR 0.70) 和全因死亡率 (HR 0.75) 的风险降低有关.
- MPA (≥15分钟/天) 与初级结局的风险较低相关 (HR 0.76),并显示出降低全因死亡率的趋势 (HR 0.80).
结论:
- 在SPRINT研究中的高风险高血压患者中,VPA和MPA都与心血管事件风险降低有关.
- VPA 显著降低了全因死亡风险,突出显示了该群体定期体力活动的重要性.
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