在人类中,骨头作为内分泌器官调节能量新陈代谢的证据
1Kogod Center on Aging and Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota.
Current opinion in endocrine and metabolic research
|August 14, 2023
概括
骨作为内分泌器官,通过像骨素这样的激素影响能量代谢. 莱普是一种关键的代谢激素,也通过同情神经系统影响骨健康,为骨损失提供潜在的治疗点.
科学领域:
- 内分泌学 在内分泌学.
- 骨生物学 骨生物学 骨生物学
- 代谢过程中的代谢.
背景情况:
- 骨传统上被视为结构支持.
- 新出现的证据强调了骨在全身调节中的作用.
- 越来越多地认识到与其他组织的相互作用.
研究的目的:
- 审查人类骨作为内分泌器官的证据.
- 探索骨和能量代谢之间的双向关系.
- 讨论同情神经系统在骨调节中的作用.
主要方法:
- 对人类和动物研究的审查.
- 专注于由骨分泌的内分泌因子 (骨质素,脂素2,RANKL,硬质素).
- 通过同情神经系统检查叶素对骨代谢的影响.
主要成果:
- 骨衍生因素 (骨素,脂素2,RANKL,硬质素) 调节能量代谢.
- 莱普通过同情神经系统影响骨代谢.
- 交感神经系统在人类骨循环中起着重要作用.
结论:
- 骨作为一个内分泌器官,调节能量代谢.
- 骨和代谢途径之间存在双向通信.
- 准交感神经系统可能为骨质损失提供治疗策略,特别是绝经后的骨质损失.
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