老年男性的心理压力和表观遗传衰老:VA规范衰老研究
Jamaji C Nwanaji-Enwerem1,2, Andres Cardenas3, Xu Gao4
1Gangarosa Department of Environmental Health, Emory Rollins School of Public Health, Atlanta, GA, USA.
Translational medicine of aging
|August 14, 2023
概括
心理压力可能会减缓老年男性的表观遗传衰老,但高压力水平可能会加速它. 这项研究探讨了感知压力和生物衰老标志物之间的复杂关系.
科学领域:
- 老年学是一门学科.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 心理压力研究 心理压力研究
背景情况:
- 心理压力是导致发病和死亡的重要危险因素.
- 以前对老年人的研究报告了关于感知压力和表观遗传衰老标志物的反直觉发现.
- 表观遗传钟,基于DNA甲基化的衰老标记,预测疾病和死亡率.
研究的目的:
- 研究自我报告的心理压力与九种不同的表观遗传钟之间的关系.
- 复制和扩展现有的关于老年男性压力和表观遗传衰老的研究.
主要方法:
- 在VA规范性衰老研究中分析了607名男性参与者的数据 (平均年龄为73.2岁).
- 使用14项感知压力尺度 (PSS) 评估压力.
- 从使用HumanMethylation450 BeadChip和各种表观遗传时钟的DNA甲基化数据计算表观遗传年龄.
主要成果:
- 感知压力尺度 (PSS) 分数的增加与Horvath和内在表观遗传年龄的减缓有关 (PSS的标准偏差增加:分别为β = -0.35年和β = -0.40年).
- 在压力水平最高的参与者中 (≥第75百分位),对于Horvath (β = 2.29年) 和内在 (β = 2.06年) 表观遗传年龄,关联转向年龄加速.
- 结果根据人口,生活方式和健康因素进行了调整.
结论:
- 心理压力和表观遗传衰老之间的关系是复杂的,潜在的非线性.
- 研究结果表明,虽然一般压力可能会减缓老年男性的表观遗传衰老,但非常高的压力水平可能会加速它.
- 需要进一步的研究来探索纵向关联和诸如弹性等因素的影响.
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