根据选定的植物化学参数,对Mangifera indicaL.叶种类进行化学分类;对制药原材料标准化的影响
Bruhan Kaggwa1,2, Maria Gloria Nakayita2, Edson Ireeta Munanura2
1Mbarara University of Science and Technology, Pharm-Bio Technology and Traditional Medicine Centre (PHARMBIOTRAC), P.O. Box 1410, Mbarara, Uganda.
Evidence-based complementary and alternative medicine : eCAM
|August 14, 2023
概括
这项研究描述了15种乌干达的Mangifera indica叶品种,根据植物化学物质含量和抗氧化活性建立了质量等级. 使用HPLC指纹来验证材料的真实性,有助于草药产品的质量控制.
科学领域:
- 植物化学 植物化学
- 药理学是指药理学,即药理学是指药理学.
- 植物认证 植物认证
背景情况:
- 红 (Mangifera indica) 叶在草药中被广泛使用.
- 在M. indica种类中存在显著的植物化学变异.
- 缺乏标准化的专著,阻碍了种植,加工和认证.
研究的目的:
- 为了描述15种乌干达的M. indica叶品种.
- 根据植物化学概况和抗氧化活性建立质量等级.
- 开发HPLC指纹识别方法,用于材料认证.
主要方法:
- 提取指数 (EI),总含量 (TPC),抗氧化活性 (AOA) 和曼吉费林度 (MC) 被量化.
- 高性能液态染色学 (HPLC) 用于指纹分析.
- 阶层分类 (HC) 和主要组件分析 (PCA) 用于质量分级和数据分析.
主要成果:
- 在15种M. indica品种中观察到EI,TPC,AOA和MC的显著变化.
- 使用HC建立了四个质量等级 (A-D),A等级展示了最高的TPC,MC和AOA.
- 通过HPLC指纹检测,发现了不同的模式,PCA识别了关键化合物,并使未知样本能够与特定品种进行聚类.
结论:
- EI,TPC,AOA和MC值可以监测M. indica材料和生产过程的质量.
- 生成的质量等级有助于选择用于种植和制造的材料.
- HPLC指纹提供了一种可靠的方法来验证M. indica材料的真实性,支持符合GMP的植物识别.
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