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关于HR+/HER2+转移性乳腺癌治疗的观点不断变化

Mark Pegram¹, Richard Pietras^2,3, Chau T Dang^4,5

¹Stanford Comprehensive Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building/SIM 1, 265 Campus Drive, Ste G2103, Stanford, CA 94305-5456, USA.

Therapeutic advances in medical oncology

|August 14, 2023

概括

激素受体阳性/HER2阳性 (HR+/HER2+) 乳腺癌需要新的治疗方法. 对HR和HER2通路的双重向提供了一种合理的方法来克服耐药性并改善HR+/HER2+乳腺癌晚期的结果.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
翻译研究是翻译研究.

背景情况:

激素受体阳性/人表皮生长因子受体2-阳性 (HR+/HER2+) 乳腺癌 (BC) 约占美国BC病例的10%.
这种亚型包括HER2+BCs是ER+,PR+,或两者 (三重阳性BC).
目前的第一线疗法 (抗HER2抗体加上化疗) 是有效的,但可能受到内异质性和受体交叉声波的限制.

研究的目的:

审查针对HER2和雌激素受体 (ER) 途径的联合受体阻断的科学和临床理由.
探索双HR和HER2路径向的潜力,以克服高级HR+/HER2+BC患者的治疗耐药性.
讨论新兴的向疗法,包括CDK4/6和PI3K/AKT/mTOR通路抑制剂,用于组合疗法.

主要方法:

审查已发表的科学文献和临床试验数据.
分析双受体通路阻塞的理由.
研究参与受体交叉通话和潜在治疗点的信号通路.

主要成果:

激素受体 (HR) 和HER2之间的交叉声可以导致治疗耐药性.
双HR和HER2通路向是一种合理的策略,可以预防耐药性并提高疗效.
目前对双重向方法的临床试验数据有限,突出显示需要进一步调查.

结论:

针对HER2和ER的组合受体阻塞是高级HR+/HER2+乳腺癌的有希望的策略.
需要研究包括CDK4/6和PI3K/AKT/mTOR途径抑制剂在内的新组合.
需要进行进一步的临床试验,以评估HR+/HER2+BC的双重向治疗方案的疗效和安全性.

关键词:

这是一种CDK4/6抑制剂.HR+/HER2+ 乳腺癌的治疗方法转移性乳腺癌转移性乳腺癌电阻的电阻是指电阻的电阻三重阳性乳腺癌是什么

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