血清C在2型糖尿病新发功能障碍中的预测作用:一项纵向观察性研究
Dongmei Sun1, Yifei Hu1, Yongjun Ma1
1Department of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.
Frontiers in endocrinology
|August 14, 2023
概括
血清C-水平可以预测2型糖尿病 (T2D) 患者的新发性功能障碍. 结合C-和其他因素的后勤回归模型显示了指导临床风险评估的高预测效率.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 糖尿病研究研究 糖尿病研究
背景情况:
- 之前的研究发现,在2型糖尿病 (T2D) 中,禁食C和功能障碍之间存在非线性关系.
- 这项研究调查了血清C对T2D患者新发功能障碍的预测作用.
研究的目的:
- 探索血清C在预测新发功能障碍中的作用.
- 使用血清C和临床参数,开发功能障碍风险的预测模型.
主要方法:
- 在T2D患者的长度观察研究中,基线功能正常.
- 拉索回归确定了关键预测因素;物流回归 (LR) 构建了预测模型.
- 使用AUC,精度,灵敏度和特异性评估模型性能;进行功率分析.
主要成果:
- 21.08%的受试者在2年内出现功能障碍.
- 确定了六个预测因素:白蛋白与肌素的比率,HbA1c,高血压,RBP与肌素的比率,禁食C四分位数和C比率四分位数.
- 该LR模型的AUC为0.83,准确率为75.80%,灵敏度为88.60%,特异性为70.80%,统计功率为0.81.
结论:
- 基线血清C-水平对于预测T2D新发功能障碍有价值.
- 开发的LR模型在临床实践中显示了个性化功能障碍风险评估的高效率.
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