植物制造的银纳米颗粒的抗菌活性使用Carica papaya L.对抗阴性细菌
Mbarga Manga Joseph Arsene1,2, Podoprigora Irina Viktorovna1,2, Marukhlenko Alla3
1Department of Microbiology V.S. Kiktenko, Medical Institute, RUDN University named after Patrice Lumumba, Moscow, Russia.
Veterinary world
|August 14, 2023
概括
番茄种子和根提取物有效合成银纳米颗粒 (AgNPs),具有显著的抗微生物和抗菌膜特性,可以对抗阴性细菌,为抗生素耐药性提供了一种新的方法.
科学领域:
- 纳米技术纳米技术
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 格拉姆阴性细菌的抗生素耐药性构成了全球健康的重大威胁.
- 农业和畜牧业受到抗生素耐药性的严重影响.
- 迫切需要新的抗微生物策略来减轻这种风险.
研究的目的:
- 为了合成银纳米颗粒 (AgNPs) 使用木瓜提取物.
- 为了评估这些AgNP对格拉姆阴性细菌的抗微生物和抗菌膜活性.
- 研究AgNP对大肠杆菌的作用机制.
主要方法:
- AgNPs的生物合成使用木瓜种子,根和树皮的水性提取物.
- 使用UV-Vis,XRD,FTIR和PCCS进行AgNP的表征.
- 通过盘扩散,MIC和MBC测定来评估抗菌活性.
- 在大肠杆菌上阐明了抗生物膜活性和作用机制.
主要成果:
- 从番茄根 (PR-AgNPs) 和种子 (PS-AgNPs) 中成功植物制造AgNP.
- 无论是PR-AgNP还是PS-AgNP,都表现出广泛的抗微生物和抗菌膜活性.
- 与PS-AgNP相比,PR-AgNP的疗效略高.
- 机制涉及干扰大肠杆菌的生长动力学和H+ATPase质子.
结论:
- 番茄种子和根提取物对AgNPs的生物合成有效.
- 合成的AgNP具有显著的抗菌和抗菌膜特性.
- 建议进行进一步的研究,以确定植物化学物质和阐明合成机制.
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