以社区为中心的疾病严重程度评估与代谢功能障碍相关的脂肪肝疾病
Jee-Fu Huang1,2,3,4, Pei-Chien Tsai1, Ming-Lun Yeh1,2,3
1Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung.
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 和代谢问题患有较瘦个体的高级纤维化率更高. 型肝炎病毒 (HCV) 感染在MAFLD患者中强烈预测了晚期纤维化.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 肝脏纤维化 肝脏纤维化
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 包含不同患者群体,疾病严重程度各不相同.
- 了解跨MAFLD诊断类别的纤维化进展对于有针对性的干预至关重要.
研究的目的:
- 评估不同诊断组的MAFLD患者的纤维化阶段和特征.
- 调查与MAFLD中晚期纤维化相关的风险因素.
主要方法:
- 一项多中心,横截面的研究包括1,948名接受肝病查的成年MAFLD患者.
- 根据MAFLD标准,患者被分为几组:2型糖尿病 (A组),BMI>23公斤/平方米 (B组) 和BMI ≤23公斤/平方米与代谢因素 (C组).
- 晚期纤维化是由纤维化-4指数>2.67来定义的.
主要成果:
- 在1,948名MAFLD患者中,已在125名患者中发现了先进的纤维化.
- 与A组 (7.6%) 和B组 (5.8%) 相比,C组 (含代谢因子的瘦身MAFLD) 的晚期纤维化患病率显著更高 (25.0%).
- 晚期纤维化的独立预测因素包括HBV/HCV共感染,HCV感染,C组分类和TC/LDL-C水平.
结论:
- 具有代谢异常的瘦身MAFLD患者代表了晚期纤维化风险较高的群体.
- 型肝炎病毒感染是MAFLD中晚期纤维化相关的重要危险因素.
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