新兴证据将肝脏与心血管系统联系起来:来自肝脏的分泌因子
Xiang Liu1,2, Yijia Shao3, Linjiang Han1,2
1Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Journal of clinical and translational hepatology
|August 14, 2023
概括
肝脏衍生分泌因子 (LDSF) 在心血管疾病 (CVD) 中至关重要. 了解肝心相互作用可能会为动脉样硬化和心力衰竭等疾病揭示新的治疗点.
科学领域:
- 心血管医学 心血管医学
- 肝病学 肝病学是一种肝病学.
- 分子生物学分子生物学
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 新出现的证据强调了肝脏衍生的分泌因子 (LDSF) 在心血管疾病调节中的作用.
研究的目的:
- 审查LDSF在各种心血管疾病中的作用.
- 探索LDSFs影响心血管系统的机制.
- 为了强调肝脏健康和心血管结果之间的联系.
主要方法:
- 对调查LDSF和CVD的研究的文献综述.
- 对LDSF成分 (微生物代谢产物,EV,蛋白质,微RNA) 的分析.
- 检查心血管系统中的LDSF目标和信号通路.
主要成果:
- 包括代谢物,EV,蛋白质和microRNA在内的LDSFs由肝脏合成并影响心血管细胞.
- LDSFs调节关键通路,例如氧化信号,炎症和氧化应激.
- 存在有争议的发现,需要进一步研究特定的LDSF功能及其在心血管疾病中的因果作用.
结论:
- LDSF在心血管健康和疾病中发挥着重要作用.
- 需要进一步的研究来阐明因果关系和治疗潜力.
- 早期识别肝脏异常对于心血管保健至关重要,倡导多学科方法.
相关概念视频
Lipid-derived Compounds in the Human Body
4.4K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.4K
Liver Regeneration
3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K
Liver Physiology
635
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
635
Role of Hematopoietic Growth Factors
1.4K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
1.4K
Regulation of the Cardiovascular System
1.2K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
1.2K
Blood Studies for Cardiovascular System III: Serum Lipid Profile
194
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
194


