智利喘儿童上呼吸道微生物群的表征揭示了组成,功能和结构上的差异
Ignacio Ramos-Tapia1, Katiuska L Reynaldos-Grandón2, Marcos Pérez-Losada3
1Centro de Bioinformática y Biología Integrativa, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.
Frontiers in allergy
|August 14, 2023
概括
智利的儿童喘与不同的鼻腔细菌有关. 这项研究确定了鼻腔细菌的较低多样性和喘儿童中菌的过度丰富性,这表明了早期检测的潜在生物标志物.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 儿科 儿科 儿科
背景情况:
- 喘在全球影响1.55亿人,智利儿童患病率为15%,严重影响医疗保健.
- 诸如宿主遗传学,抗生素的使用和呼吸道微生物群的发展等因素都与喘的病因有关.
- 了解上呼吸道的细菌组对于破译喘的复杂起源至关重要.
研究的目的:
- 描述和比较喘儿童和智利健康儿童的鼻腔和口腔粘膜细菌组.
- 为了确定与智利圣地亚哥的儿科喘相关的潜在微生物分类学和功能生物标志物.
- 在智利儿科队列中探索上呼吸道细菌和喘之间的关系.
主要方法:
- 使用16SrRNA高通量测序分析了来自63名喘患者和89名健康儿童的鼻腔和口腔粘膜样本.
- 微生物组成,多样性 (α和β) 和共发生网络被分析到两个身体部位.
- 与鼻腔粘膜相关的功能途径使用元基因组分析来确定.
主要成果:
- 与健康对照组相比,在喘儿童的鼻腔粘膜中观察到明显较低的α多样性和过度丰富的链球菌 (Streptococcus) (P < 0.001和P < 0.01,分别).
- 鼻微生物群社区结构和微生物相互作用在喘和健康儿童之间有所不同,确定了不同的关键基石属.
- 两组人口粘膜中没有发现微生物分类学或功能多样性的显著差异;然而,在喘患者的鼻粘膜中检测到51个差异丰富的功能通路.
结论:
- 在圣地亚哥的儿童的鼻腔中,存在着与喘相关的独特细菌群落.
- 减少鼻腔细菌多样性和过度丰富的链球菌可能成为儿童喘的潜在生物标志物.
- 这项研究首次探索了与智利喘有关的上呼吸道细菌组,突出了鼻腔微生物群的作用.
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