初级保健血液检测显示,在前症状的肌缩性侧面硬化症中,脂质特征发生变化
Alexander G Thompson1, Rachael Marsden1, Kevin Talbot1
1Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Brain communications
|August 14, 2023
概括
代谢变化,特别是胆固醇水平的变化,发生在肌缩性侧面硬化症运动症状显现之前的几年. 这些症状前的变化可能为未来的生物标志物和治疗点提供帮助.
科学领域:
- 神经学 神经学
- 代谢医学是一种代谢医学.
- 生物化学 生物化学
背景情况:
- 代谢变化越来越被认为是神经退行性疾病的潜在前体.
- 肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病,其特征是运动神经元损失.
- 了解ALS的症状前变化对于开发早期诊断工具和干预措施至关重要.
研究的目的:
- 在肌缩侧面硬化症运动症状出现之前,调查例行测量血液指数的变化.
- 为了确定ALS潜在的症状前代谢生物标志物.
- 探索与ALS症状发作有关的代谢变化的时间动态.
主要方法:
- 从ALS患者和英国生物库对照中回顾性分析病前血液数据 (胆固醇,甘油三,HbA1c,肌素).
- 线性混合效应模型与b-splines用于识别代谢标记物的拐点.
- 在统计模型中对年龄和性别进行控制.
主要成果:
- 在专家诊所和英国生物银行队列中,在ALS症状出现前几年观察到总和LDL胆固醇水平的下降.
- 高密度高脂胆固醇显示了类似的趋势,尽管不那么一致.
- 症状出现后肌素水平显著下降,这表明了明显的时间模式.
- 甘油三水平保持稳定,HbA1c档案在队列之间不一致.
结论:
- 动态的代谢变化,特别是胆固醇,是ALS的症状前阶段的特征.
- 这些发现支持基于血液的代谢标志物的潜力,用于早期发现ALS.
- 识别症状前的代谢变化可以指导ALS的预防疗法的开发.
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