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Updated: Jul 19, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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中等尺度DNA特征的影响APOBEC3A和APOBEC3B除酶活动和形状瘤突变景观

Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani

    bioRxiv : the preprint server for biology
    |August 14, 2023
    PubMed
    概括

    编辑DNA的酶APOBEC3A (阿波蛋白B mRNA编辑酶,催化多类3A) 和APOBEC3B (阿波蛋白B mRNA编辑酶,催化多类3B) 产生了不同的癌症突变模式. 它们独特的序列偏好决定了这些突变在DNA中发生的位置.

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    Epigenetic Regulation01:37

    Epigenetic Regulation

    Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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